CD Markers
CD53

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 28 December 2015, last major update February 2002

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD53
Definition / General
  • Most specific and reliable pan-leukocyte marker
  • Encodes member of tetraspanin family, a cell surface protein with 4 hydrophobic domains that mediate signal transduction
  • Also has adhesion / activation functions
  • Upregulated in macrophages exposed to lipopolysaccharide (Mol Cells 2004;17:125)
  • May transduce CD2-generated signals in T cells and natural killer cells
  • May be a thymocyte selection marker, with CD69 (Int Immunol 2002;14:249)
  • Familial deficiency is associated with recurrent infectious diseases (Clin Diagn Lab Immunol 1997;4:229)
  • References: OMIM #151525
Uses by Pathologists
  • No significant clinical use by pathologists
Positive Staining - Normal
Positive Staining - Disease
  • Radioresistant tumor cells
Negative Staining
  • Platelets, red blood cells and non-hematopoietic cells