CD Markers
CD55

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 28 December 2015, last major update February 2002

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD55[title]
Cite this page: CD55. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd55.html. Accessed December 6th, 2016.
Definition / General
  • Also called complement decay accelerating factor (DAF)
  • Gene encodes Cromer blood group
  • Binds C3bBb (alternative pathway convertase) and C4b2a (classical pathway convertase) to accelerate decay of the C3 convertases; protects against inappropriate complement activation (J Biol Chem 2005;280:2569)
  • Receptor for CD97, echovirus (Proc Natl Acad Sci U S A 2002;99:10325) and Coxsackie B virus (J Virol 1998;72:9407)
  • Also is part of lipopolysaccharide-induced receptor complex (Eur J Immunol 2003;33:1399)
  • Genetic defects that cause a reduction or loss of both CD59 and CD55 on erythrocytes produce paroxysmal nocturnal hemoglobinuria (PNH); also cause defective platelets, granulocytes, erythrocytes and possibly lymphocytes
  • CD55 deficiency is common in patients treated with Campath (anti-CD52), which may predispose to PNH (Transplant Proc 2006;38:1750)
  • A minor population of CD55-CD59 negative granulocytes and red blood cells predicts a good response to immunosuppressive therapy in patients with acquired aplastic anemia (Blood 2006;107:1308)
  • Loss of CD55 is associated with poor prognosis in breast cancer (Clin Cancer Res 2004;10:2797); however high expression is associated with poor prognosis in colorectal carcinoma (Cancer Immunol Immunother 2003;52:638)
  • References: OMIM #125240
Case Reports
Uses by Pathologists
Micro Images

Images hosed on other servers:

Breast carcinoma staining

Positive Staining - Normal
  • All hematopoietic cells and all cell types in intimate contact with complement proteins
  • Also epithelial cells lining extracellular compartments, body fluids and extracellular matrix