CD Markers
CD58

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 28 December 2015, last major update February 2002

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD58[title]
Definition / General
Uses by Pathologists
Micro Images

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Buccal mucosa: stratified squamous epithelium (LFA-3+)


Cardiac muscle: intercalated discs and capillary endothelium (LFA-3+)


Cerebellum: cortical microglia (A, LFA-3+); liver: Kupffer cells (B, LFA-3+); skin: epidermal dendritic cell (C, LFA-3 +)


Kidney: proximal tubule (LFA-3+, p) and distal tubule (d) epithelial cells with central, spherical nuclei (LFA-3 negative)


Testis: cells close to seminiferous tubule boundary, reminiscent of Sertoli cells

Positive Staining - Normal
  • Leukocytes (but not mature B cells), pre B cells, erythrocytes, endothelial cells, epithelial cells, fibroblasts and cardiac muscle (J Clin Pathol 1990;43:893)
Positive Staining - Disease
Negative Staining
  • Mature B cells