CD Markers
CD59

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 28 December 2015, last major update February 2002

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD59[title]
Definition / General
  • Also called protectin, complement regulatory molecule
  • Regulates complement mediated cell lysis by inhibiting formation of membrane attack complex (MAC); binds to C8 or C9 components, preventing incorporation of multiple copies of C9 required for complete formation of osmolytic core
  • Also makes cells susceptible to NK cell mediated cytotoxicity (J Immunol 2006;176:2915)
  • Genetic defects that reduce both CD59 and CD55 on erythrocytes produce paroxysmal nocturnal hemoglobinuria (PNH); also cause defective platelets, granulocytes, erythrocytes and possibly lymphocytes
  • Low CD59 levels may also cause PNH-like symptoms after Campath therapy (Transplant Proc 2006;38:1750)
  • Not a particularly good marker for detecting PNH+ monocytes (Am J Clin Pathol 2006;126:781)
  • In diabetes, glycation may inhibit CD59, causing MAC deposition in vessels, leading to vascular complications (Diabetes 2004;53:2653)
  • Naegleria (Infect Immun 2006;74:1189), Borrelia (J Immunol 2003;170:3214) and HIV (J Gen Virol 1997;78:1907) may resist complement mediated lysis via a surface CD59 like protein
  • References: OMIM #107271
Uses by Pathologists
  • No significant clinical use by pathologists
Micro Images

Images hosed on other servers:

Diabetic and nondiabetic:
kidneys (left), nerves (right)

Positive Staining - Normal
  • Most cells
Positive Staining - Disease