CD Markers

Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 January 2016, last major update August 2013

Copyright: (c) 2002-2016,, Inc.

PubMed Search: CD6

Cite this page: CD6. website. Accessed October 24th, 2016.
Definition / General
  • Adhesion molecule mediating binding of developing thymocytes with thymic epithelial cells (OMIM #186720)
  • Belongs to ancient scavenger receptor superfamily; at #11q13
  • Also called T cell differentiation antigen, T12
  • Essential for stable contact between T cells and antigen presenting cells, which leads to T cell proliferation (Blood 2006;107:3212)
  • Binds to CD166 (ALCAM)
  • Monomeric 105 or 130kD membrane glycoprotein; size difference is due to differences in phosphorylation (Eur J Immunol 1995;25:2765)
  • May be signaling attenuator whose expression alone is sufficient to restrain signaling in T cells (Eur J Immunol 2012;42:195)
Clinical Features
Uses by Pathologists
  • No significant clinical use by pathologists
Micro Images

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Brain (CD6-)


Kidney (CD6-)

Skeletal muscle (CD6-)


Uterus (CD6-)

Positive Staining - Normal
  • Mature T cells, B cell subset (B1 cells), NK cells (subset, J Innate Immun 2011;3:420), CNS cells
  • High levels on mature (medullary) thymocytes, low levels on immature (cortical) thymocytes