CD Markers
CD61

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 28 December 2015, last major update February 2002

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD61[title]
Cite this page: CD61. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd61.html. Accessed December 3rd, 2016.
Definition / General
  • Also called integrin beta 3 chain (ITGB3)
  • Combines with CD41 (integrin alpha IIb) to form platelet glycoprotein IIb/IIIa, a receptor for fibrinogen, fibronectin, plasminogen, prothrombin, thrombospondin, vitronectin and von Willebrand factor
  • Combines with CD51 to form receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor
  • CD51-CD61 is present on endothelium, endothelial cells, smooth muscle, some B cells, monocytes, macrophages, platelets, osteoclasts, mast cells, fibroblasts and tumor cells
  • Platelet activation causes a conformation change in GPIIb/IIIa, enabling the binding of soluble fibrinogen and forming a platelet plug
  • CD61 defects cause Glanzmann thrombasthenia, an autosomal recessive disorder and the most common inherited platelet disease
  • CD61 has role in pathogenesis of asthma (Am J Respir Crit Care Med 2005;172:67)
  • Polymorphisms may cause premature coronary artery disease (Arch Pathol Lab Med 1999;123:1223)
  • High pre-kidney transplant levels associated with acute rejection (Transplant Proc 2003;35:1360)
  • References: J Clin Invest 2005;115:3363 (review), OMIM #173470
Uses by Pathologists
Micro Images

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AML-M7


AML-M7; #5 (figs C, D)

Dysplastic megakaryocytes

Positive Staining - Normal
  • Platelets, megakaryocytes, myeloid progenitor cells and endothelial cells
Positive Staining - Disease
Negative Staining
  • AML M0-M5, M6 (most)