CD Markers
CD64

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 28 December 2015, last major update February 2002

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD64[title]
Cite this page: CD64. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd64.html. Accessed December 7th, 2016.
Definition / General
  • Also called Fc gamma RI
  • High affinity receptor binds to Fc region of IgG
  • Important in phagocytosis via receptor-mediated endocytosis of IgG-antigen complexes
  • Mediates antigen capture for presentation to T cells, antibody-dependent cellular cytotoxicity, release of cytokines and reactive oxygen intermediates
  • Also binds to C reaction protein and mediates its effects (J Biol Chem 2005;280:25095)
  • Denge fever immune complexes enter macrophages via CD64 (J Virol 2006;80:10128)
  • References: OMIM #146760
Uses by Pathologists
Positive Staining - Normal
  • Antigen presenting cells including macrophages / monocytes, activated granulocytes and dendritic cells; also early myeloid cells
Positive Staining - Disease
Negative Staining
  • AML M7
Flow Cytometry Images

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Levels in patient with elevated neutrophil CD64