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CD Markers
CD66

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 12 November 2014, last major update February 2002
Copyright: (c) 2002-2014, PathologyOutlines.com, Inc.
PubMed Search: CD66

See also   CD66aCD66bCD66cCD66dCD66eCD66f   below

CD66a

General
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Uses by pathologists
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Micro images
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Cutaneous melanoma

Metastatic melanoma

Colon


Expression at maternal-fetal surface

Various breast lesions

Positive staining - normal
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Positive staining - disease
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Negative staining
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CD66b

General
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Uses by pathologists
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Micro images
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Polymorphonuclear leucocytes

Positive staining - normal
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Positive staining - disease
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CD66c

General
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Uses by pathologists
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Positive staining - normal
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Positive staining - disease
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CD66d

General
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Uses by pathologists
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Positive staining - normal
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CEA / CD66e

General
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Case reports
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Uses by pathologists
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Micro images
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Ampulla of Vater-Paneth cell carcinoma (figure G)

Breast adenoid cystic carcinoma (fig 13)

Cervical adenocarcinoma: signet ring cell type (fig D)

Cervical adenocarcinoma: intestinal differentiation (fig D)


Cervical adenoid cystic carcinoma

Colon inverted hyperplastic polyp (normal colon at upper right is CEA-)

Gastric adenocarcinoma metastatic to colon (fig 4)


Hepatocellular carcinoma (polyclonal CEA)

Hepatocellular carcinoma: clear cell variant (fig A)

Liver: poorly differentiated adenocarcinoma (figure 4D)

Hepatocellular carcinoma
vs. cholangiocarcinoma
(note different staining patterns)


Lung adenocarcinoma metastatic to ovary (figure 2B)

Medullary thyroid carcinoma (fig 7)

Pagetís disease of vulva (fig 11)

Pagetís disease of scrotum


Secretory meningioma (left, fig 10; right, fig 11)

Peritoneal benign multicystic mesothelioma
(an atypical finding, fig 2F)


Sweat gland carcinoma
(fig 8B)

Various images: quality control


Cytology images
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Cholangiocarcinoma (fig 8)

Positive staining - normal
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Positive staining - tumors
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Negative staining
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CD66f

General
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Uses by pathologists
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Micro images
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Implanted ovum (CD66f+, syncytiotrophoblast)

Normal placenta (CD66f+, trophoblast)

Hydatidiform mole (syncytiotrophoblast)

Invasive mole (CD66f+, large trophoblast cells)


Choriocarcinoma of uterus (CD66f+, syncytiotrophoblast);
note absence of staining in cytotrophoblast

Positive staining - normal
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Positive staining - disease
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End of CD Markers > CD66


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