CD Markers

Author: Nat Pernick, M.D.

Revised: 7 May 2018, last major update November 2014

Copyright: (c) 2003-2018,, Inc.

PubMed Search: pregnancy-specific beta-1 glycoprotein

Related topics: General, CD66b, CD66c, CD66e / CEA, CD66f

Page views in 2018: 8
Page views in 2019 to date: 7
Cite this page: Pernick, N. CD66f. website. Accessed August 20th, 2019.
Definition / general
  • Also called pregnancy-specific beta-1 glycoprotein, PSG1
  • May be involved in immune regulation, protection of fetus from maternal immune system
  • Released into maternal circulation during pregnancy
  • Low levels in maternal blood predict spontaneous abortion
  • References: OMIM #176390
Uses by pathologists
  • No significant clinical use by pathologists
Microscopic (histologic) images

Images hosted on other servers:

Implanted ovum (CD66f+, syncytiotrophoblast)

Normal placenta (CD66f+, trophoblast)

Hydatidiform mole (syncytiotrophoblast)

Invasive mole (CD66f+, large trophoblast cells)


Choriocarcinoma of uterus
(CD66f+, syncytiotrophoblast);
note absence of staining in

Positive staining - normal
  • Syncytiotrophoblasts, fetal liver and myeloid cells
Positive staining - disease
Back to top