CD Markers
CD68




Topic Completed: 01 February 2002

Revised: 14 December 2018, last major update February 2002

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: CD68[title]
Page views in 2018: 14,724
Page views in 2019 to date: 1,093
Cite this page: Pernick N. CD68. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd68.html. Accessed January 23rd, 2019.
Definition / general
  • Also called KP1, macrosialin
  • May have role in macrophage phagocytic activities
  • Specific to lysosomes, not cell lineage; epithelial cells activated by E. coli may be CD68+ (Toxicol In Vitro 2002;16:405)
  • Binds to tissue and organ specific lectins or selectins, allowing homing of macrophage subsets to particular sites
  • References: OMIM #153634, Am J Clin Pathol 2004;122:794
Uses by pathologists
  • Marker of histiocytes and histiocytic tumors
  • Presence in postportoenterostomy liver biopsies for extrahepatic biliary atresia is associated with favorable prognosis (J Pediatr Surg 2005;40:1252)
Microscopic (histologic) images

Images hosted on PathOut server:

Atypical epithelioid angiomyolipoma of kidney



Images hosted on other servers:

Acute demyelinating disease (fig 9)

AML-M5 (fig 5b)

Breast carcinoma: treatment effect (fig 3)

Cholesterol granuloma of temporal bone

Castleman’s disease (Figure 16)

Chronic myelomonocytic leukemia with eosinophilia
(fig C)

Crohn’s disease

Crystal storing histiocytosis within lymphoma (fig 9)

Endometrial nodular histiocytic hyperplasia
(fig 3)

Erdheim-Chester disease: #1-lung (fig 5); #2-liver (fig 5)

Follicular dendritic cell tumor (fig 13)

Gastrointestinal stromal tumor with osteoclast-like giant cells (fig b)

Gaucher’s disease (presumptive) in spleen

Giant cell granuloma of temporal bone (fig C)

Granular cell tumor (fig 2B)

Histiocytic sarcoma (fig 5)

HIV associated encephalopathy

Juvenile xanthogranuloma: adult (fig 4)

Kikuchi’s disease (fig 13)

Kikuchi-like lymphadenopathy #1 in lupus

Kupffer cells in alcoholic liver disease (fig 6)

Leiomyosarcoma with osteoclast-like giant cells (fig D)

Multiple sclerosis

Myeloid sarcoma #1-uterus, #2-lymph nodes

Plexiform fibrohistiocytic tumor (fig 3)

Plasmacytoid monocyte tumor

Rosai-Dorfman disease (fig D)

Splenic hamartoma (figure 3B)

Thyroid gland giant cell granuloma
(fig C)

Viral myocarditis

Xanthogranulomatous pyelonephritis (fig 4)


Positive staining - normal
Positive staining - tumors
Negative staining