CD Markers
CD68



Topic Completed: 1 February 2002

Revised: 27 August 2019

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: CD68[title]

Nat Pernick, M.D.
Page views in 2018: 14,724
Page views in 2019 to date: 12,399
Cite this page: Pernick N. CD68. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd68.html. Accessed September 17th, 2019.
Definition / general
  • Also called KP1, macrosialin
  • May have role in macrophage phagocytic activities
  • Specific to lysosomes, not cell lineage; epithelial cells activated by E. coli may be CD68+ (Toxicol In Vitro 2002;16:405)
  • Binds to tissue and organ specific lectins or selectins, allowing homing of macrophage subsets to particular sites
  • References: OMIM #153634, Am J Clin Pathol 2004;122:794
Uses by pathologists
  • Marker of histiocytes and histiocytic tumors
  • Presence in postportoenterostomy liver biopsies for extrahepatic biliary atresia is associated with favorable prognosis (J Pediatr Surg 2005;40:1252)
Microscopic (histologic) images
Scroll to see all images:


Images hosted on PathOut server:

Atypical epithelioid angiomyolipoma of kidney



Images hosted on other servers:

Missing Image

Acute demyelinating disease (fig 9)

Missing Image

AML-M5 (fig 5b)

Missing Image

Breast carcinoma: treatment effect (fig 3)

Missing Image

Cholesterol granuloma of temporal bone

Missing Image

Castleman's disease (Figure 16)

Missing Image

Chronic myelomonocytic leukemia with eosinophilia
(fig C)


Missing Image

Crohn's disease

Missing Image

Crystal storing histiocytosis within lymphoma (fig 9)

Missing Image

Endometrial nodular histiocytic hyperplasia
(fig 3)

Missing Image Missing Image

Erdheim-Chester disease: #1-lung (fig 5); #2-liver (fig 5)

Missing Image

Follicular dendritic cell tumor (fig 13)


Missing Image

Gastrointestinal stromal tumor with osteoclast-like giant cells (fig b)

Missing Image

Gaucher's disease (presumptive) in spleen

Missing Image

Giant cell granuloma of temporal bone (fig C)

Missing Image

Granular cell tumor (fig 2B)

Missing Image

Histiocytic sarcoma (fig 5)

Missing Image

HIV associated encephalopathy


Missing Image

Juvenile xanthogranuloma: adult (fig 4)

Missing Image

Kikuchi's disease (fig 13)

Missing Image Missing Image Missing Image

Kikuchi-like lymphadenopathy #1 in lupus

Missing Image

Kupffer cells in alcoholic liver disease (fig 6)


Missing Image

Leiomyosarcoma with osteoclast-like giant cells (fig D)

Missing Image

Multiple sclerosis

Missing Image Missing Image

Myeloid sarcoma #1-uterus, #2-lymph nodes

Missing Image

Plexiform fibrohistiocytic tumor (fig 3)

Missing Image

Plasmacytoid monocyte tumor


Missing Image

Rosai-Dorfman disease (fig D)

Missing Image

Splenic hamartoma (figure 3B)

Missing Image

Thyroid gland giant cell granuloma
(fig C)

Missing Image

Viral myocarditis

Missing Image

Xanthogranulomatous pyelonephritis (fig 4)

Positive staining - normal
Positive staining - tumors
Negative staining
Back to top