CD Markers
CD73




Topic Completed: 1 February 2002

Revised: 14 December 2018, last major update February 2002

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD73[title]
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Cite this page: Pernick N. CD73. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd73.html. Accessed May 24th, 2019.
Definition / general
  • Also called ecto-5'-nucleotidase
  • Catalyzes dephosphorylation of ribo- and deoxyribonucleotides to their corresponding nucleosides, such as 5’ AMP to adenosine
  • Mediates costimulatory signals in T cell activation
  • Mediates lymphocyte adhesion to dendritic cells (Blood 1996;88:1755) and endothelium (J Immunol 2000;165:5411)
  • May protect against vascular inflammation and neointima formation (Circulation 2006;113:2120)
  • May be a lymphocyte maturation marker
  • References: OMIM #129190
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
  • B and T cell subset, endothelial cells, follicular dendritic cells and epithelial cells
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