CD Markers

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 29 December 2015, last major update February 2002

Copyright: (c) 2002-2015,, Inc.

PubMed Search: CD73[title]
Cite this page: CD73. website. Accessed October 28th, 2016.
Definition / General
  • Also called ecto-5'-nucleotidase
  • Catalyzes dephosphorylation of ribo- and deoxyribonucleotides to their corresponding nucleosides, such as 5’ AMP to adenosine
  • Mediates costimulatory signals in T cell activation
  • Mediates lymphocyte adhesion to dendritic cells (Blood 1996;88:1755) and endothelium (J Immunol 2000;165:5411)
  • May protect against vascular inflammation and neointima formation (Circulation 2006;113:2120)
  • May be a lymphocyte maturation marker
  • References: OMIM #129190
Uses by Pathologists
  • No significant clinical use by pathologists
Positive Staining - Normal
  • B and T cell subset, endothelial cells, follicular dendritic cells and epithelial cells