CD Markers
CD74

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 29 December 2015, last major update February 2002

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD74[title]
Cite this page: CD74. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd74.html. Accessed December 3rd, 2016.
Definition / General
  • Also called LN2, HLA-DR-associated invariant chain
  • Gamma chain antigen associated with MHC class II antigen and antigen presentation
  • MHC class II chaperone-stabilizes alpha / beta heterodimers in a complex soon after synthesis, and directs transport of the complex from the endoplasmic reticulum to compartments, where peptide loading of class II takes place
  • H. pylori urease binds to CD74 on gastric epithelial cells (Infect Immun 2006;74:1148) and upregulates CD74 expression (J Immunol 2005;175:171)
  • Has important role in mucosal immunity
  • Receptor for macrophage migration inhibitory factor, a proinflammatory cytokine (J Immunol 2006;177:8730)
  • Associated with perineural invasion in pancreatic carcinoma (Clin Cancer Res 2006;12:2419)
  • References: OMIM #142790
Uses by Pathologists
  • B cell marker (not commonly used)
Micro Images

Images hosted on other servers:

Renal tumors (figs D-F)

Multiple myelomas
(figs G-J)

Increased expression
in H. pylori+ epithelium

Positive Staining - Normal
  • B cells, activated T cells, macrophages, interdigitating dendritic cells, activated endothelial and epithelial cells
Positive Staining - Disease
Negative Staining
  • Renal oncocytoma