CD Markers
CD74



Topic Completed: 1 February 2002

Revised: 27 August 2019

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: CD74[title]

Nat Pernick, M.D.
Page views in 2018: 158
Page views in 2019 to date: 107
Cite this page: Pernick N. CD74. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd74.html. Accessed September 23rd, 2019.
Definition / general
  • Also called LN2, HLA-DR-associated invariant chain
  • Gamma chain antigen associated with MHC class II antigen and antigen presentation
  • MHC class II chaperone-stabilizes alpha / beta heterodimers in a complex soon after synthesis, and directs transport of the complex from the endoplasmic reticulum to compartments, where peptide loading of class II takes place
  • H. pylori urease binds to CD74 on gastric epithelial cells (Infect Immun 2006;74:1148) and upregulates CD74 expression (J Immunol 2005;175:171)
  • Has important role in mucosal immunity
  • Receptor for macrophage migration inhibitory factor, a proinflammatory cytokine (J Immunol 2006;177:8730)
  • Associated with perineural invasion in pancreatic carcinoma (Clin Cancer Res 2006;12:2419)
  • References: OMIM #142790
Uses by pathologists
  • B cell marker (not commonly used)
Microscopic (histologic) images

Images hosted on other servers:

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Renal tumors (figs D-F)

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Multiple myelomas
(figs G-J)

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Increased expression
in H. pylori+ epithelium

Positive staining - normal
  • B cells, activated T cells, macrophages, interdigitating dendritic cells, activated endothelial and epithelial cells
Positive staining - disease
Negative staining
  • Renal oncocytoma
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