CD Markers
CD77

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 29 December 2015, last major update February 2002

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD77
Cite this page: CD77. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd77.html. Accessed July 25th, 2017.
Definition / general
  • Also called globotriaosylceramide, CD77 synthase (OMIM #607922)
  • pK blood group antigen on erythrocytes
  • A carbohydrate, not a protein
  • Endothelial receptor for verotoxins (J Biol Chem 2006;281:10230) from Shigella dysenteriae and E. coli
  • Also expressed by liver flukes (Biol Chem 2001;382:195)
  • Interacts with CD19 (J Cell Physiol 1998;176:281)
  • Mediates apoptosis of renal vascular endothelial cells and intestinal epithelial cells, resulting in hemolytic uremic syndrome
  • Does NOT discriminate centroblasts from centrocytes
Uses by pathologists
  • Identify germinal center cells
Positive staining - normal
Positive staining - disease
  • Burkitt's lymphoma