CD Markers
CD80

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 29 December 2015, last major update February 2002

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD80[title]
Cite this page: CD80. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd80.html. Accessed December 4th, 2016.
Definition / General
  • Also called B7-1, BB1
  • T cells need two signals for activation; the first signal is antigen peptide presented on MHC class II through the T cell receptor
  • The second (costimulatory) signal is delivered by CD80 or CD86, expressed on surface of antigen presenting cells, which interact with either CD28 or CD152 (CTLA-4)
  • Has critical role in autoimmune, humoral and transplant responses
  • Increased expression may cause excessive antigen presentation in fulminant hepatic failure, as an early step in its pathogenesis before the onset of tissue damage (Am J Pathol 1999;154:1711)
  • Receptor for some adenovirus species (Virus Res 2006;122:144)
  • References: OMIM #112203
Diagrams / Tables

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CD80/86 binding and antagonism by drug abatacept

Uses by Pathologists
  • No significant clinical use by pathologists
Micro Images

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Inflamed skin

Positive Staining - Normal
  • Activated B cells, T cells, macrophages and dendritic cells