CD Markers

Topic Completed: 1 February 2002

Revised: 15 August 2019

Revised:14 December 2018, last major update February 2002

Copyright: (c) 2002-2015,, Inc.

PubMed Search: CD85

Related topics: CD85A, CD85B, CD85C, CD85D, CD85E, CD85F, CD85G, CD85H, CD85I, CD85J, CD85K, CD85L, CD85M

Nat Pernick, M.D.
Page views in 2018: 33
Page views in 2019 to date: 39
Cite this page: Pernick N. CD85. website. Accessed September 23rd, 2019.
Definition / general
  • Previously entire Immunoglobulin-like Transcript (ILT) family was clustered as CD85; now subclassified as CD85a to CD85m
  • Also called Leukocyte Immunoglobulin-like Receptors (LIR) and Monocyte/Macrophage Immunoglobulin-like Receptors (MIR)
  • CD85 itself is now called CD85J (see below)
  • Family of immunoreceptors expressed on monocytes and B cells; lower levels on dendritic cells and NK cells
  • Prevents NK / T cell killing and inhibits B cells by negative signaling receptors
  • Note: some family members have activating functions (see specific family members below)
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