CD Markers
CD85D

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 31 December 2015, last major update February 2002

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD85d

Related topics: CD85, CD85A, CD85B, CD85C, CD85E, CD85F, CD85G, CD85H, CD85I, CD85J, CD85K, CD85L, CD85M
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Cite this page: CD85D. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd85d.html. Accessed September 24th, 2019.
Definition / general
  • Also called ILT4, LIR2, MIR10, LILRB2
  • Down regulates the immune response; involved in the development of tolerance
  • Upregulated by HLA-G in antigen-presenting cells, NK cells, and T cells (FASEB J 2005;19:662)
  • Interacts with human leukocyte antigen A, B, and G molecules and transmits negative signals that interfere with the activation of monocytes and dendritic cells (Hum Immunol 2004;65:700)
  • Also competes with CD8A for binding to class I MHC antigens
  • IL-10 renders dendritic cells hypostimulatory by upregulating cell surface CD85D and by inhibiting soluble CD85D in vitro (Eur J Immunol 2004;34:74); similar effect on endothelial cells (Eur J Immunol 2006;37:177)
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
Additional references
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