CD Markers

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 30 December 2015, last major update February 2002

Copyright: (c) 2002-2015,, Inc.

PubMed Search: CD87
Definition / General
  • Also called urokinase plasminogen activator receptor (uPA-R), PLAUR
  • Membrane protein responsible for plasmin expression on cells
  • Binds both the proprotein and mature forms of urokinase plasminogen activator
  • Subject to negative feedback regulation by uPA, which cleaves it to an inactive form
  • Implicated in metastasis - receptors for uPA and plasmin are found at leading edge of tumor cells; plasmin causes hydrolysis of extra-cellular matrix proteins in the path of cellular invasion
  • Plasma levels of different soluble receptors are increased and predict mortality in HIV patients (J Acquir Immune Defic Syndr 2005;39:23)
  • Pre-storage leukofiltration reduces transfusion reactions, perhaps due to reduction in soluble CD87 (Transfus Med 2004;14:305)
  • Hypoxia (Exp Mol Med 2004;36:57) and glucose deprivation (Exp Cell Res 2006;312:1685) may induce tumor invasion and metastases by upregulating CD87
  • Upregulated by dialysis, and associated with clinical findings (Blood Purif 2006;24:236)
  • Receptor for Group A Streptococcus (J Mol Biol 2005;350:27)
Uses by Pathologists
  • No significant clinical use by pathologists
Micro Images

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Endometrial adenocarcinoma

Pancreatic adenocarcinoma (figures B, D)

Positive Staining - Normal
Positive staining - Tumors
Negative Staining
Additional References