CD Markers
CD89



Topic Completed: 1 February 2002

Minor changes: 3 September 2019

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD89

Nat Pernick, M.D.
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Cite this page: Pernick N. CD89. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd89.html. Accessed July 7th, 2020.
Definition / general
  • Also called FCAR, FCalphaR
  • IgA Fc receptor, binds IgA and eliminates IgA coated targets
  • Induces phagocytosis, degranulation, respiratory burst and killing of microorganisms
  • Pathogenic group A and group B streptococci produce virulence factors that block the binding of IgA to CD89, inhibiting IgA-mediated immunity (J Biol Chem 2006;281:1389)
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
  • Neutrophils, monocytes/macrophages, activated eosinophils, alveolar and splenic macrophages, interstitial dendritic cells
Negative staining
Additional references
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