CD Markers
CD89

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 30 December 2015, last major update February 2002

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD89
Cite this page: CD89. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd89.html. Accessed December 10th, 2016.
Definition / General
  • Also called FCAR, FCalphaR
  • IgA Fc receptor, binds IgA and eliminates IgA coated targets
  • Induces phagocytosis, degranulation, respiratory burst and killing of microorganisms
  • Pathogenic group A and group B streptococci produce virulence factors that block the binding of IgA to CD89, inhibiting IgA-mediated immunity (J Biol Chem 2006;281:1389)
Uses by Pathologists
  • No significant clinical use by pathologists
Positive Staining - Normal
  • Neutrophils, monocytes/macrophages, activated eosinophils, alveolar and splenic macrophages, interstitial dendritic cells
Negative Staining
Additional References