CD Markers

Topic Completed: 1 September 2013

Minor changes: 3 September 2019

Copyright: (c) 2003-2018,, Inc.

PubMed Search: CD94[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CD94. website. Accessed September 23rd, 2020.
Definition / general
  • Also called natural killer cell antigen, kP43, killer cell lectin-like receptor subfamily D member 1, KLRD1
  • Receptor for MHC class I HLA-E molecules present on NK cells and some cytotoxic T cells
  • Inhibits NK cell activation by disrupting the actin network where the NK cell contacts its ligand (J Immunol 2006;177:3590)
  • Increased numbers of CD94+ NK cells in active and inactive ulcerative colitis (Hepatogastroenterology 2001;48:1316); increased number of CD94+ T cells in chronic plaque psoriasis (Br J Dermatol 2006;155:318)
Uses by pathologists
Microscopic (histologic) images

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Normal tonsil

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Nasal type, extranodal NK / T cell lymphoma (figure C)

Positive staining - normal
  • NK cells, CD8+ T cells
Positive staining - disease
Additional references
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