CD Markers
CD94

Author: Nat Pernick, M.D. (see Authors page)

Revised: 26 July 2018, last major update September 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: CD94[title]
Cite this page: Pernick, N. CD94. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd94.html. Accessed October 19th, 2018.
Definition / general
  • Also called natural killer cell antigen, kP43, killer cell lectin-like receptor subfamily D member 1, KLRD1
  • Receptor for MHC class I HLA-E molecules present on NK cells and some cytotoxic T cells
  • Inhibits NK cell activation by disrupting the actin network where the NK cell contacts its ligand (J Immunol 2006;177:3590)
  • Increased numbers of CD94+ NK cells in active and inactive ulcerative colitis (Hepatogastroenterology 2001;48:1316); increased number of CD94+ T cells in chronic plaque psoriasis (Br J Dermatol 2006;155:318)
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:

Normal tonsil

Nasal type, extranodal NK / T cell lymphoma (figure C)

Positive staining - normal
  • NK cells, CD8+ T cells
Positive staining - disease
Additional references