Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 5 September 2013, last major update February 2002
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
PubMed Search: CD94[title]
- Also called natural killer cell antigen, kP43, killer cell lectin-like receptor subfamily D member 1, KLRD1
- Receptor for MHC class I HLA-E molecules present on NK cells and some cytotoxic T-cells
- Inhibits NK cell activation by disrupting the actin network where the NK cell contacts its ligand (J Immunol 2006;177:3590)
- Increased numbers of CD94+ NK cells in active and inactive ulcerative colitis (Hepatogastroenterology 2001;48:1316); increased number of CD94+ T cells in chronic plaque psoriasis (Br J Dermatol 2006;155:318)
Nasal-type, extranodal NK/T cell lymphoma (figure C)
Positive staining (normal)
Positive staining (disease)
End of CD Markers > CD94
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