CD Markers
CD94

Author: Nat Pernick, M.D. (see Authors page)

Revised: 30 December 2015, last major update September 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CD94[title]
General
  • Also called natural killer cell antigen, kP43, killer cell lectin-like receptor subfamily D member 1, KLRD1
  • Receptor for MHC class I HLA-E molecules present on NK cells and some cytotoxic T-cells
  • Inhibits NK cell activation by disrupting the actin network where the NK cell contacts its ligand (J Immunol 2006;177:3590)
  • Increased numbers of CD94+ NK cells in active and inactive ulcerative colitis (Hepatogastroenterology 2001;48:1316); increased number of CD94+ T cells in chronic plaque psoriasis (Br J Dermatol 2006;155:318)
Uses by Pathologists
Micro Images

Images hosted on other servers:

Normal tonsil

Nasal-type, extranodal NK/T cell lymphoma (figure C)

Positive Staining - Normal
  • NK cells, CD8+ T cells
Positive Staining - Disease
Additional References