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Table of Contents
Definition / General | Uses by Pathologists | Micro Images | Positive Staining - Normal | Positive Staining - Disease | Negative Staining | Additional ReferencesDefinition / General
- Binds to CD55 and G protein-coupled receptors
- May be involved in cell adhesion and signaling processes early after leukocyte activation
- May be involved in migration of neutrophils (J Immunol 2004;172:1125)
- Highly expressed at sites of inflammation in skin, lung and rheumatoid arthritis
- May contribute to angiogenesis associated with tumors (Blood 2005;105:2836)
- Glycosylation causes CD97 to show two different epitopes, EGF and Stalk (Int J Cancer 2004;112:815)
Uses by Pathologists
- No significant clinical use by pathologists
Micro Images
Images hosted on other servers:
Normal oral mucosa
Gastric carcinoma
Oral squamous cell carcinoma
Positive Staining - Normal
- Activated T > B cells, monocytes/macrophages, dendritic cells, granulocytes, smooth muscle cells
Positive Staining - Disease
- GI carcinomas (Oncol Rep 2005;14:1413, Am J Clin Pathol 2002;118:699), thyroid carcinoma (stronger if undifferentiated, J Clin Endocrinol Metab 1999;84:1104)
Negative Staining
- Microglia
Additional References
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