General
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• Binds to CD55 and G protein-coupled receptors
• May be involved in cell adhesion and signaling processes early after leukocyte activation
• May be involved in migration of neutrophils (J Immunol 2004;172:1125)
• Highly expressed at sites of inflammation in skin, lung and rheumatoid arthritis
• May contribute to angiogenesis associated with tumors (Blood 2005;105:2836)
• Glycosylation causes CD97 to show two different epitopes, EGF and Stalk (Int J Cancer 2004;112:815)

Uses
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• No significant clinical use by pathologists

Micro images
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Normal oral mucosa

Gastric carcinoma

Oral squamous cell carcinoma

Thyroid carcinoma

Thyroid (various)

Positive staining (normal)
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• Activated T > B cells, monocytes/macrophages, dendritic cells, granulocytes, smooth muscle cells

Positive staining (disease)
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• GI carcinomas (Oncol Rep 2005;14:1413, Am J Clin Pathol 2002;118:699), thyroid carcinoma (stronger if undifferentiated, J Clin Endocrinol Metab 1999;84:1104)

Negative staining
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• Microglia

References
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• Tissue Antigens 2001;57:325, OMIM 601211

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