CD Markers

Author: Nat Pernick, M.D. (see Authors page)

Revised: 26 July 2018, last major update September 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: CD97
Cite this page: Pernick, N. CD97. website. Accessed October 19th, 2018.
Definition / general
  • Binds to CD55 and G protein-coupled receptors
  • May be involved in cell adhesion and signaling processes early after leukocyte activation
  • May be involved in migration of neutrophils (J Immunol 2004;172:1125)
  • Highly expressed at sites of inflammation in skin, lung and rheumatoid arthritis
  • May contribute to angiogenesis associated with tumors (Blood 2005;105:2836)
  • Glycosylation causes CD97 to show two different epitopes, EGF and Stalk (Int J Cancer 2004;112:815)
Uses by pathologists
  • No significant clinical use by pathologists
Microscopic (histologic) images

Images hosted on other servers:

Normal oral mucosa

Gastric carcinoma

Oral squamous cell carcinoma

Positive staining - normal
  • Activated T > B cells, monocytes / macrophages, dendritic cells, granulocytes, smooth muscle cells
Positive staining - disease
Negative staining
  • Microglia