CD Markers
CD97
Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.
PubMed Search: CD97
CD97
Author: Nat Pernick, M.D.
Topic Completed: 1 September 2013
Minor changes: 3 September 2019
Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.
PubMed Search: CD97
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative staining | Additional referencesCite this page: Pernick N. CD97. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd97.html. Accessed July 7th, 2020.
Definition / general
- Binds to CD55 and G protein-coupled receptors
- May be involved in cell adhesion and signaling processes early after leukocyte activation
- May be involved in migration of neutrophils (J Immunol 2004;172:1125)
- Highly expressed at sites of inflammation in skin, lung and rheumatoid arthritis
- May contribute to angiogenesis associated with tumors (Blood 2005;105:2836)
- Glycosylation causes CD97 to show two different epitopes, EGF and Stalk (Int J Cancer 2004;112:815)
Uses by pathologists
- No significant clinical use by pathologists
Microscopic (histologic) images
Images hosted on other servers:
Normal oral mucosa
Gastric carcinoma
Oral squamous cell carcinoma
Positive staining - normal
- Activated T > B cells, monocytes / macrophages, dendritic cells, granulocytes, smooth muscle cells
Positive staining - disease
- GI carcinomas (Oncol Rep 2005;14:1413, Am J Clin Pathol 2002;118:699), thyroid carcinoma (stronger if undifferentiated, J Clin Endocrinol Metab 1999;84:1104)
Negative staining
- Microglia
Additional references
