Cervix
Carcinoma
Epithelioid trophoblastic tumor

Author: Branko Perunovic, M.D. (see Authors page)

Revised: 18 April 2017, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: Epithelioid trophoblastic tumor cervix

Cite this page: Epithelioid trophoblastic tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixETT.html. Accessed April 27th, 2017.
Definition / General
  • Rare tumor (100 cases reported) in women of reproductive age with abnormal vaginal bleeding
  • Associated with a gestational event, mean 6 years prior
  • Usually elevated serum hCG
  • In uterine fundus, lower uterine segment or endocervix
  • Neoplastic counterpart to placental site nodule, with malignant intermediate trophoblast
  • Metastases in 25%, death in 10%; similar behavior as placental site trophoblastic tumor; less aggressive than choriocarcinoma
Case Reports
Gross Images

Images hosted on other servers:

Expansile mass with fleshy cut surface

Micro Description
  • Resembles placental site trophoblastic tumor
  • Invasive nodules of monomorphic intermediate-sized intermediate trophoblast cells with abundant eosinophilic or clear cytoplasm, medium/large irregular nuclei with distinct nucleoli; occasional multinucleated cells
  • Tumor cells surround extensive necrosis and hyaline-like matrix
  • 2+ mitotic figures/10 HPF
  • At periphery, tumors infiltrate normal tissue in small round nests or cords, including focal replacement of surface or glandular epithelium with stratified neoplastic cells
  • Often decidualized stroma nearby
  • Usually no definite SIL
Micro Images

Images hosted on other servers:

Various images

Uterine tumor with coexisting choriocarcinoma

Negative Stains
Differential Diagnosis