Large cell keratinizing squamous cell carcinoma

Author: Branko Perunovic, M.D. (see Authors page)

Revised: 15 May 2017, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed search: Large cell keratinizing squamous cell carcinoma

Related Topic: Squamous cell carcinoma
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Cite this page: Large cell keratinizing squamous cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixLCSCC.html. Accessed October 20th, 2019.
Definition / general
  • Rare, locally aggressive; spreads by direct extension
  • More radioresistant than nonkeratinizing carcinomas (5 year survival for stage I is 54%)
  • Not associated with HPV or SIL; not associated with sexual risk factors
  • Often normal Pap smear but may be large and high stage at diagnosis
  • Histologically similar to HPV negative vulvar and penile cancers
Microscopic (histologic) images

Images hosted on other servers:

Multiple keratin pearls

Molecular / cytogenetics description
  • HPV negative by PCR
Additional references
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