Benign / nonneoplastic lesions
Microglandular hyperplasia

Topic Completed: 1 May 2007

Revised: 27 December 2018, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: Microglandular hyperplasia cervix

Branko Perunovic D.M.
Farnaz Hasteh, M.D.
Page views in 2018: 9,876
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Cite this page: Hasteh F., Perunovic B. Microglandular hyperplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixMGH.html. Accessed September 22nd, 2019.
Definition / general
  • Benign, nonneoplastic proliferation of endocervical glands
  • Also called microglandular adenosis, microglandular change
Clinical features
  • Common in reproductive aged women
  • Associated with birth control pills (progestins) or pregnancy in young women, although also present in postmenopausal women
  • Usually incidental, may grow as a polypoid mass
Gross description
  • Polypoid, single or multiple
  • Early lesions are sessile
Microscopic (histologic) description
  • Complex proliferation of small back to back glands lined by cuboidal, columnar or flattened cells with prominent vacuoles above / below vesicular nuclei
  • Indistinct nucleoli, usually no atypic
  • May be associated with immature or mature squamous metaplasia
  • May have areas of solid growth, mucin pools (resembling colloid carcinoma), pseudoinfiltrative pattern, signet ring cells, focal atypia, occasional mitotic figures, acute and chronic inflammation, hobnail cells
Microscopic (histologic) images

Images hosted on PathOut server:

Dense glands but no atypia

Solid pattern

Images hosted on other servers:

Possible involvement by HSIL

Cytology description
  • Uniform glandular cells with fenestration or microacini (Acta Cytol 1999;43:110)
  • Bi or tridimensional cellular clusters of cubic or cylindrical glandular cells with vacuolated cytoplasm, also cells with dense cytoplasm and basaloid cells
  • Often has an immature metaplastic pattern (Diagn Cytopathol 2004; 30:57)
  • Also reserve cells with scant cytoplasm and small, round nuclei
  • May have plasma cells or other inflammatory cells
  • May have cytologic atypia (Diagn Cytopathol 1994; 10:326) due to hyperchromatic crowded groups, nuclear enlargement, hyperchromasia
  • Cells may have multiple nucleoli, mitotic figures, apoptotic bodies and focal, watery diathesis (Acta Cytol 2000; 44:661)
Negative stains
Differential diagnosis
Additional references
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