Cervix
Benign / nonneoplastic lesions
Microglandular hyperplasia

Author: Branko Perunovic, M.D. (see Authors page)

Revised: 28 April 2017, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: Microglandular hyperplasia cervix

Cite this page: Microglandular hyperplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixMGH.html. Accessed July 25th, 2017.
Definition / general
  • Also called micro glandular adenosis, micro glandular change
  • Common cervical lesion associated with birth control pills or pregnancy in young women, although also in postmenopausal women
  • Usually incidental, may grow as a polypoid mass
Gross description
  • Polypoid, single or multiple
  • Early lesions are sessile
Microscopic (histologic) description
  • Complex proliferation of small back to back glands lined by cuboidal, columnar or flattened cells with prominent vacuoles above / below vesicular nuclei
  • Indistinct nucleoli, usually no atypic
  • May be associated with immature or mature squamous metaplasia
  • May have areas of solid growth, mucin pools (resembling colloid carcinoma), pseudoinfiltrative pattern, signet ring cells, focal atypia, occasional mitotic figures, acute and chronic inflammation, hobnail cells
Microscopic (histologic) images

Images hosted on PathOut server:

Dense glands but no atypia

Solid pattern



Images hosted on other servers:

Possible involvement by HSIL

Cytology description
Negative stains
Differential diagnosis
Additional references