Papillary squamourothelial carcinoma

Author: Branko Perunovic, M.D. (see Authors page)

Revised: 17 May 2017, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed search: Papillary squamourothelial carcinoma [title] cervix

Related topic: Squamous cell carcinoma
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Cite this page: Papillary squamourothelial carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixPSC.html. Accessed October 21st, 2019.
Definition / general
  • Rare, resembles urothelial carcinoma but lacks true urothelial differentiation (J Low Genit Tract Dis 2005;9:149)
  • May behave aggressively with late metastases and local recurrence
  • Usually postmenopausal women who present at advanced stage (Eur J Gynaecol Oncol 1998;19:455)
  • Superficial biopsies with this pattern should be considered invasive until proven otherwise
Microscopic (histologic) description
  • Papillary architecture with fibrovascular cores lined by multilayered, basaloid / urothelial type epithelium with mitotic activity and without maturation, resembling HSIL
  • Stromal invasion is usually at base of tumor but may be within fibrovascular core
Microscopic (histologic) images

Images hosted on PathOut server:

Papillae covered by atypical basal cells

Focal squamous differentiation

Infiltration of stroma

Positive stains
Molecular / cytogenetics description
Differential diagnosis
Additional references
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