Premalignant / preinvasive lesions
SIL variants

Topic Completed: 1 May 2007

Revised: 27 December 2018, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: SIL Variant cervix

See subtypes below: Keratinizing SILHSIL with immature metaplastic differentiationHSIL with eosinophilic dysplasia

Branko Perunovic D.M.
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Cite this page: Perunovic B. SIL Variants. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixSILvariant.html. Accessed October 18th, 2019.
Keratinizing SIL
Cytology description

HSIL with immature metaplastic differentiation
Differential diagnosis
  • Air drying artifact
  • Papillary immature metaplasia: papillary not flat, less nuclear pleomorphism and atypia

HSIL with eosinophilic dysplasia
Definition / general
  • Present in 10% of HSIL lesions
  • Associated with HPV infection and classic HSIL in adjacent areas
  • May arise from metaplastic cervical squamous epithelium that has become infected with high risk HPV
Microscopic (histologic) description
  • Lack of normal maturation
  • Compared to classic HSIL, cells have distinct cell borders and abundant eosinophilic cytoplasm, increased N/C ratio and focal dysplastic nuclei with nuclear enlargement, hyperchromasia, variable nuclear membrane abnormalities and distinct nucleoli
  • Associated with classic SIL and squamous metaplasia
Positive stains
Differential diagnosis
Additional references
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