- DES was given to women in 1950's to prevent miscarriages (although it didn't actually do so)
- In utero DES exposure is associated with: (a) adenosis of vagina and cervix and infertility in female offspring and (b) testicular abnormalities in male offspring (Cochrane Database Syst Rev 2003;(3):CD004353)
- Tubal-type endocervical glandular proliferations resembling minimal deviation adenocarcinoma occur in women with DES exposure, may be a form of DES-related adenosis (Int J Gynecol Pathol 2005;24:391)
End of Cervix > Benign / non-neoplastic lesions > Adenosis
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