Sarcoma / lymphoma / other
Aggressive angiomyxoma

Author: Dr. Branko Perunovic (see Author page)

Revised: 3 November 2015, last major update May 2007

Copyright: (c) 2007-2015, PathologyOutlines.com, Inc.

PubMed Search: Aggressive angiomyxoma cervix

Definition / General
  • First described in female pelvis in 1983 (Am J Surg Pathol 1983;7:463)
  • Very rarely reported in cervix
  • Usually large, bulky mass of deep soft tissue of pelvicoperineal region of young adult women and men
  • High risk of local recurrence, but only rare metastases (Hum Pathol 2003;34:1072)
Gross Description
  • Gelatinous, up to 60 x 20 cm, locally infiltrative
Micro Description
  • Bland-appearing myofibroblastic tumor composed of scanty spindled and stellate cells in loose stromal matrix with collagen fibrils, prominent vasculature including thick walled vessels
  • May infiltrate locally
  • No/rare mitotic figures, no atypia
Micro Images
Not necessarily cervix:

Bland hypocellular mesenchymal tumor

Negative Stains
Molecular / Cytogenetics Description
  • Rearrangement of HMGIC gene
Electron Microscopy Description
  • Myofibroblastic features
Additional References