Cervix
Inflammatory / infectious
CMV
Author: Branko Perunovic, D.M.
Last author update: 1 May 2007
Last staff update: 30 March 2022
Copyright: 2007-2024, PathologyOutlines.com, Inc.
PubMed Search: CMV cervix
Table of Contents
Definition / general | Epidemiology | Case reports | Treatment | Microscopic (histologic) description | Microscopic (histologic) images | Cytology descriptionCite this page: Perunovic B. CMV. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixcmv.html. Accessed April 25th, 2024.
Definition / general
- Uncommon condition in cervix
- Patients are usually NOT immunocompromised (J Clin Pathol 2004;57:691)
- Viral shedding common in HIV+ women (J Med Virol 1999;59:469)
Epidemiology
- Rarely seen in Pap test
- Associated with HIV1 infection (J Med Virol 1999; 59:469)
- Some cases have no associated risk factors (J Clin Pathol 2004; 57:691, Cytopathology 1993; 4:237)
Case reports
- 16 year old girl (Diagn Cytopathol 2009;37:836)
- 20 year old woman with endocervical biopsy (Pathology 1991;23:318)
Treatment
- No treatment in healthy people
Microscopic (histologic) description
- Large, basophilic intranuclear inclusions or intracytoplasmic eosinophilic inclusions in occasional endocervical glandular epithelial cells
- Inclusions also in endothelial and stromal cells but not squamous cells
- Associated with fibrin thrombi, dense acute inflammatory infiltrate, lymphoid follicles, vacuoles in glandular cells, reactive changes in glandular epithelial cells
Microscopic (histologic) images
Images hosted on other servers:
Intracytoplasmic inclusions #1 (endocervical cells)
#2 (endothelial cells)
CMV+ glands and stroma
Associated acute inflammatory infiltrate
Intracytoplasmic vacuoles within endocervical glandular cells
Fibrin thrombi within small vessels
Not cervix:
Lung #1 - Giemsa stain
Kidney
Pancreas
Cytology description
- Involvement of glandular and squamous cells
- Cellular enlargement, nuclear enlargement and large nuclear inclusion surrounded by a halo "owl's eye"
- Occasionally smaller nuclear or cytoplasmic inclusions
