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Revised: 17 September 2010, last major update August 2010
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Definition / general
● HPV testing may be more sensitive than cytology in detecting HSIL (Br J Cancer 2005;93:575)
● Prevalence of HPV DNA positivity, clinical value of HPV test and positive predictive value for dysplasia varies according to age group (American Journal of Obstetrics and Gynecology 2007;197(4), 346-355)
● HPV testing is an integral part of management of ASCUS (atypical squamous cells of uncertain significance), ASC-H (atypical squamous cells, cannot exclude HSIL) and to evaluate AGUS (atypical glandular cells, Am J Obstet Gynecol 2005;193:559)
● Study of simultaneous FISH for HPV E6 and E7 mRNA had 83% sensitivity and 91% sensitivity for high grade SIL compared with Pap smear in 231 liquid based cytology samples (Am J Clin Path 2005;123:716)
Cervix-cytology > HPV testing
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