Cervix - Cytology
Atypia / premalignant / preinvasive lesions
HSIL / CIN III / severe dysplasia

Topic Completed: 1 June 2011

Revised: 27 December 2018, last major update June 2011

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed search: HSIL CIN III severe dysplasia

Marilin Rosa, M.D.
Page views in 2018: 3,816
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Cite this page: Rosa M. HSIL / CIN III / severe dysplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixcytologyHSILCINIII.html. Accessed September 24th, 2019.
  • Also called carcinoma in situ
  • Due to high risk HPV infection
Clinical features
Cytology description
  • Usually single, small, round / oval cells with scant cytoplasm and increased N/C ratio (greater than 1/2)
  • Nuclear membrane does not have sharp angles
  • Nuclei vary markedly in contour and have irregular coarsely clumped chromatin
  • No macronucleoli, no tumor diathesis
Cytology images

Images hosted on other servers:

Various images

Haphazard nuclei with
clumped chromatin
and hyperchromasia

HSIL in pregnant patient

HSIL, suspicious for invasion


Differential diagnosis
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