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Normal cells / non-neoplastic findings

PM cells

Reviewer: Farnaz Hasteh, M.D., UCSD Medical Center (see Reviewers page)
Revised: 7 December 2010, last major update December 2010
Copyright: (c) 2006-2010, PathologyOutlines.com, Inc.


● Cells from PeriMenopausal women

Clinical features

● Significant cause of ASC overdiagnosis in women ages 40 to 55 years (Am J Clin Pathol 2005;124:58)
● ASCUS appears to have a particularly low positive predictive value for SIL in perimenopausal women, and therefore most likely is overcalled in this age group; this may be attributable in part to air-drying artifact and subtle atrophic changes (Cancer 2001;93:100)
● Reporting benign EMs for premenopausal women 40 years and older has little clinical significance (Am J Clin Pathol 2005;123:571)
● ASC-H is associated with HSIL in 22% in perimenopausal women (Am J Clin Pathol 2006;126:381)

Cytology description

● Squamous cells with enlarged, smooth, bland nuclei in perimenopausal women
● In early menopause, there is an intermediate cell maturation pattern (DeMay: The Pap Test: Exfoliative Gynecologic Cytology (1st Ed); ASCP, 2005)

End of Cervix-cytology > Normal cells / non-neoplastic findings > PM cells

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