Cervix - cytology
Signet ring cell

Author: Ashwyna Sunassee, M.D. (see Authors page)
Editor: Ryan Askeland, M.D.

Revised: 10 August 2018, last major update April 2015

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Signet ring cell carcinoma[title] cervix
Cite this page: Sunassee, A. Signet ring cell adenocarcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixcytologyadenocarcinomasignet.html. Accessed October 15th, 2018.
Definition / general
  • Associated with high risk HPV
Clinical features
Case reports
Gross description
Microscopic (histologic) images

Images hosted on other servers:
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Neoplastic signet ring cells

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CA125+, CEA+, p16+, vimentin-

Cytology description
  • Large vacuole of mucin pushes nuclei to periphery (World J Surg Oncol 2012;10:7)
  • May have prominent nucleoli
  • Note that squamous cell carcinoma may have distended degenerative vacuoles that resemble signet ring cells
Positive stains
  • CEA, CK7, CA125, p16
  • Note:
    • Immunoreactivity to colorectal antigens such as CEA, CDX2 and CK20 in a cervical lesion does not rule out a diagnosis of primary cervical carcinoma
    • Simultaneous CEA+ and CK7+ does not differentiate primary cervical signet ring cell carcinoma and mammary metastatic malignancy (World J Surg Oncol 2012;10:7)
Negative stains
Differential diagnosis