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Cervix-Cytology

Adenocarcinoma of cervix - signet ring cell

Reviewer: Marilin Rosa, M.D., University of Florida (see Reviewers page)
Revised: 7 June 2011, last major update June 2011
Copyright: (c) 2006-2011, PathologyOutlines.com, Inc.

Definition
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● Primary signet ring cell adenocarcinoma of the cervix is unusual - metastatic signet ring adenocarcinoma to the cervix is more common (Int J Gynecol Pathol 2007;26:254)

Etiology
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● Associated with high risk HPV

Cytology description
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● Large secretory vacuoles push nuclei to periphery
● May have prominent nucleoli
● Note that squamous cell carcinoma may have distended degenerative vacuoles that resemble signet ring cells

Differential diagnosis
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● Metastatic carcinoma from breast or stomach (Acta Cytol 2000;44:824)

End of Cervix-cytology > Carcinoma > Adenocarcinoma of cervix - signet ring cell

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