Cervix - Cytology
Adenoid basal

Author: Ashwyna Sunassee, M.D. (see Authors page)
Editor: Ryan Askeland, M.D.

Revised: 3 May 2017, last major update November 2014

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: Adenoid basal [title]
Cite this page: Cytology - Adenoid basal. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixcytologyadenoidbasal.html. Accessed October 17th, 2017.
Definition / general
  • Very rare indolent tumor with favorable clinical course and excellent prognosis
  • Affects older postmenopausal women, often non - white
  • Usually diagnosed retrospectively on surgical specimens
  • Rare metastasis
  • Genetic studies have shown correlation with viral infection, particularly HPV type 16 (Hum Pathol 2005;36:82)
  • p53 gene alterations including wild type hyperexpression and p53 point mutation damage have been noted
Clinical features
  • ~80% of patients are asymptomatic at initial diagnosis
  • 80 - 90% come to clinical attention due to abnormal pap smear - usually a high - grade squamous intraepithelial lesion
Prognostic factors
  • Morphologically pure lesions usually have favorable outcome
Case reports
Gross description
  • Normal cervix without any obvious lesion
Microscopic (histologic) description
  • Nested cellular proliferations with peripheral palisading (Diagn Pathol 2006 Aug 16;1:20)
  • Uniform, round to oval cells with scant cytoplasm, hyperchromatic nuclei with inconspicuous nucleoli and minimal nuclear atypia
  • May have microcyst formation
  • No stromal reaction
Microscopic (histologic) images

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Basaloid cells infiltrating stroma

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Small nests of round small cells

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Small acini

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Palisading arrangement

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Scattered cellular proliferations

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Ki67, p16

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Cytology description
  • Often no findings or unrecognized on cytology, as many cases do not involve surface
  • Usually associated with HSIL, and hence detected on Pap; HPV16+
  • Three dimensional, somewhat dyscohesive groups of intact small and uniform cells with overlapping nuclei (Acta Cytol 1995;39:563)
  • Scant cytoplasm (Diagn Cytopathol 1996;14:172)
  • Occasional peripheral palisading
  • Finely granular chromatin, mild hyperchromasia, small / inconspicuous nucleoli
  • "Windswept appearance" when compared to reactive atypia (Acta Cytol 1995;39:563)
Positive stains
Negative stains
Differential diagnosis