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Cervix-Cytology

Atypia / premalignant / preinvasive lesions

Atypical repair

Reviewer: Marilin Rosa, M.D., University of Florida (see Reviewers page)
Revised: 8 June 2011, last major update June 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Definition
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● Part of ASC-US category in Bethesda 2001
● 5% incidence of SIL in one study (Diagn Cytopathol 2005;33:214)

Cytology
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● Few cohesive tissue fragments, uniform nuclei, chromatin with increased chromatin granules, hyperchromasia, prominent nucleoli, scarce mitotic activity
● Liquid based cytology: scattered atypical squamous cells with prominent nucleoli and other evidence of reparative change; also more obvious nuclear pleomorphism, anisonucleosis, nuclear outline irregularities, coarsening of chromatin and focal loss of nuclear polarity (Cancer 2003;99:141)

Differential Diagnosis
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● Poorly differentiated squamous cell carcinoma or adenocarcinoma

End of Cervix-cytology > Atypia / premalignant / preinvasive lesions > Atypical repair

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