Benign / nonneoplastic lesions
Benign features

Topic Completed: 1 November 2010

Revised: 20 December 2018, last major update November 2010

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PubMed search: non neoplastic lesions benign cervix

Farnaz Hasteh, M.D.
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Cite this page: Hasteh F. Benign features (cytology). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixcytologybenignfeatures.html. Accessed January 27th, 2020.
Cytology description
  • Evenly distributed heterochromatin and euchromatin
  • Chromatin granules are small and uniformly distributed (versus coarse and uniform in lymphocytes and ovarian granulosa cells)
  • Chromatin is sharp and crisp
  • No hyperchromasia (in contrast, lymphocytes are usually hyperchromatic)
  • Nuclear membranes are smooth
  • Chromatin rims have uniform thickness
  • Nucleoli are conspicuous but not large and not prominent (but are more conspicuous if reactive or biosynthetic activity is present)
  • Honeycomb configuration when viewed en face
  • Transparent cytoplasm in squamous or transitional cells suggests benign and mature cells
  • Immature benign cells have high N/C ratio, denser cytoplasm, vesicular nuclei
Differential diagnosis
  • Reactive changes, due to any type of stimuli (pH change, hormonal changes, inflammatory causes) may resemble dysplasia
Additional references
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