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Benign / non-neoplastic lesions

Benign features

Reviewer: Farnaz Hasteh, M.D., UCSD Medical Center (see Reviewers page)
Revised: 17 November 2010, last major update November 2010
Copyright: (c) 2006-2010, PathologyOutlines.com, Inc.

Cytology description

● Evenly distributed heterochromatin and euchromatin
● Chromatin granules are small and uniformly distributed (versus coarse and uniform in lymphocytes and ovarian granulosa cells)
● Chromatin is sharp and crisp
● No hyperchromasia (in contrast, lymphocytes are usually hyperchromatic)
● Nuclear membranes are smooth
● Chromatin rims have uniform thickness
● Nucleoli are conspicuous but not large and not prominent (but are more conspicuous if reactive or biosynthetic activity is present)
● Honeycomb configuration when viewed en face
● Transparent cytoplasm in squamous or transitional cells suggests benign and mature cells
● Immature benign cells have high N/C ratio, denser cytoplasm, vesicular nuclei

Differential diagnosis

● Reactive changes, due to any type of stimuli (pH change, hormonal changes, inflammatory causes) may resemble dysplasia


Cytopathology 2005;16:295

End of Cervix-cytology > Benign / non-neoplastic lesions > Benign features

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