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Inflammation / parasites
Reviewer: Farnaz Hasteh, M.D., UCSD Medical Center (see Reviewers page)
Revised: 25 October 2010, last major update October 2010
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● Uncommon condition in cervix
● Rarely seen in Pap Test
● Associated with HIV1 infection (J Med Virol 1999;59:469)
● Some cases have no associated risk factors (J Clin Pathol 2004;57:691, Cytopathology 1993;4:237)
● CMV is a DNA virus, and member of herpes virus family
● 16 year old girl (Diagn Cytopathol 2009;37:836)
● 20 year old woman with endocervical biopsy (Pathology 1991;23:318)
● No treatment in healthy people
● Involvement of glandular and squamous cells
● Cellular enlargement, nuclear enlargement and large nuclear inclusion surrounded by a halo “owl’s eye”
● Occasionally smaller nuclear or cytoplasmic inclusions
● Multinucleation with no nuclear molding
Cervix-cytology > Inflammation / parasites > CMV
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