Cervix - Cytology
Cytopathology Competency / Milestone Assessment - The Pap Test
2. Benign Cellular Changes

Topic Completed: 1 January 2014

Revised: 3 January 2019, last major update January 2014

Copyright: (c) 2014-2017, PathologyOutlines.com, Inc.

PubMed search: Benign Cellular Changes [title]

Zubair W. Baloch, M.D., Ph.D.
Ricardo R. Lastra, M.D.
Page views in 2018: 822
Page views in 2019 to date: 435
Cite this page: Lastra R., Baloch Z. Cytology - Benign Cellular Changes. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixcytologycompbenign.html. Accessed August 24th, 2019.
Medical knowledge
  1. Recognize normal benign squamous proliferative reactions according to their cytoplasmic and nuclear features
    • Reserve cell hyperplasia
    • Immature squamous metaplasia
    • Mature squamous metaplasia
  2. Recognize normal benign glandular proliferative reactions according to their cytoplasmic and nuclear features
    • Reactive endocervical cells
    • Microglandular endocervical hyperplasia
    • Tubal metaplasia
  3. Understand the clinical significance of the benign squamous and glandular proliferative reactions
  4. Understand the importance of benign squamous proliferative reactions as potential mimickers of neoplastic conditions
  5. Recognize the various keratotic reactions
    • Hyperkeratosis
    • Parakeratosis
    • Atypical parakeratosis
Practice based learning and systems based practice
  1. Understand the nuclear features that allow distinction between proliferative reactions and neoplastic conditions
  2. Identify artifacts commonly seen in benign proliferative reactions, such as spider cells and cytoplasmic vacuolization
  3. Understand the significant conditions that might be related to the various keratotic reactions
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