Cervix - Cytology
Cytopathology Competency / Milestone Assessment
7. Epithelial Cell Abnormalities

Topic Completed: 1 January 2014

Revised: 4 January 2019, last major update January 2014

Copyright: (c) 2014-2017, PathologyOutlines.com, Inc.

PubMed search: Epithelial Cell [title] Abnormalities

Ricardo R. Lastra, M.D.
Page views in 2018: 595
Page views in 2019 to date: 283
Cite this page: Lastra R. Epithelial Cell Abnormalities. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixcytologycompepithelial.html. Accessed August 23rd, 2019.
Medical knowledge
  1. Recognize atypical squamous cells of undetermined significance (ASCUS)
  2. Recognize atypical parakeratosis
  3. Recognize low grade squamous intraepithelial lesion (LSIL)
  4. Recognize high grade squamous intraepithelial lesion (HSIL)
  5. Recognize atypical squamous cells, cannot rule out high grade (ASC- H)
  6. Recognize squamous intraepithelial lesion with gland involvement
  7. Recognize squamous cell carcinoma and associated tumor diathesis and recognize the keratinizing and nonkeratinizing variants
  8. Recognize small cell carcinoma
  9. Recognize patterns of HSIL that can easily be missed
    • Rare small HSIL cells
    • Stream of HSIL cells, usually within mucus
Practice based learning and systems based practice
  1. Know how to distinguish the various categories of epithelial cell abnormalities from each other and from benign mimics
  2. Understand the role of HPV infection in the development of squamous lesions
  3. Understand that morphologic changes compatible with HPV infection (koilocytes) are considered low grade intraepithelial lesion
  4. Understand criteria used to differentiate squamous intraepithelial lesion with gland involvement from a glandular neoplasm
  5. Understand the correlation between cytologic diagnosis and the surgical pathology counterpart
  6. Understand the rate of progression of the various epithelial lesions and the implications of the diagnosis for the patient
  7. Understand the utility of reflex HPV testing after certain diagnosis and know when it is appropriate to perform this test
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