- Understand the pathophysiology of human papillomavirus (HPV) infection.
- Recognize low-risk and high-risk HPV serotypes.
- Recognize morphologic features of HPV infection (i.e. koilocytes).
- Describe the methods of detection of HPV infection.
- In situ hybridization
- Southern blot technique
- Polymerase chain reaction
- Recognize atypical immature metaplasia
Practice Based Learning
- Understand the effect of HPV infection according to the epithelium involved
- Keratinized epithelium vs. mature metaplastic epithelium
- Understand that the nuclear features are the key in differentiating true koilocytes from changes seen in certain reactive processes
- Understand the type of epithelial cell abnormality and its prognosis according to the HPV serotype present
- Understand the sensitivity of the various methods of detection of HPV infection
- Understand the most appropriate method of detection of HPV infection to be used according to the clinical scenario
- Understand that HPV related changes can coexist with high-grade dysplasia
End of Cervix - Cytology > Cytopathology Competency / Milestone Assessment > 9. Human Papillomavirus (HPV)
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