Cervix - Cytology
Cytopathology Competency / Milestone Assessment - The Pap Test
5. Cytology of Pregnancy

Topic Completed: 1 January 2014

Revised: 3 January 2019, last major update January 2014

Copyright: (c) 2014-2017, PathologyOutlines.com, Inc.

PubMed search: cervix cytology pregnancy [title] cytopathology

Zubair W. Baloch, M.D., Ph.D.
Ricardo R. Lastra, M.D.
Page views in 2018: 462
Page views in 2019 to date: 334
Cite this page: Lastra R., Baloch Z. Cytology of Pregnancy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixcytologycomppregnancy.html. Accessed October 16th, 2019.
Medical knowledge
  1. Understand the effect of hormones during pregnancy and puerperium on the cervical epithelium and the maturation index
  2. Recognize glycogenated intermediate cells or "navicular cells" characteristic of pregnancy
  3. Recognize reactive endocervical cells and increased number of histiocytes as normal changes seen in pregnancy
  4. Recognize decidual cells
  5. Recognize Arias-Stella reaction
  6. Recognize trophoblastic cells, including cytotrophoblasts and syncytiotrophoblasts
  7. Recognize noncellular elements present during pregnancy, such as radiate crystalline arrays ("Cockleburrs")
  8. Recognize characteristic changes of puerperal endometritis
  9. Understand the significance of dysplasia or carcinoma diagnosis in the Pap smear of a pregnant patient
Practice based learning and systems based practice
  1. Understand how changes in the maturation index of a pregnant patient can be explained by underlying fetal abnormalities
  2. Understand the significance of decidual cells, Arias-Stella reaction and trophoblasts as mimics of neoplastic disease
  3. Understand the differential diagnosis of multinucleated giant cells during pregnancy
    • Syncytiotrophoblasts
    • Viral infection – Herpes
    • Giant cell histiocytes
    • Dysplasia / neoplasia
  4. Understand the management of cervical neoplasia during pregnancy
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