Normal cells / nonneoplastic findings

Topic Completed: 1 August 2010

Minor changes: 26 March 2020

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PubMed search: degeneration cervix cytology

Xinmin Zhang, M.D.
Page views in 2019: 711
Page views in 2020 to date: 320
Cite this page: Zhang X. Degeneration. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixcytologydegeneration.html. Accessed June 1st, 2020.
Definition / general
  • Degenerative type changes due to delay in transfer of cells to the slide (air drying artifact), inflammation or atrophy
  • More common on conventional than liquid based preparations
  • Occasionally called retroplastic change
Cytology description
  • Cytoplasm is lost and moth eaten with vacuolization
  • Chromatin is clumped, hazy, smudged or indistinct
  • Chromatin rim has variable thickness and irregular contours but no sharp angles of malignancy
Cytology images

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Degenerated cells

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