Normal cells / nonneoplastic findings
Endometrial cells

Topic Completed: 1 August 2010

Minor changes: 26 March 2020

Copyright: 2006-2020, PathologyOutlines.com, Inc.

PubMed search: cervix endometrial cells [title]

Xinmin Zhang, M.D.
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Cite this page: Zhang X. Endometrial cells. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixcytologyendometrialcells.html. Accessed June 1st, 2020.
Definition / general
  • Spontaneously exfoliated endometrial cells are often seen during the first 12 days of the menstrual cycle
  • May also be due to hormone replacement therapy (Obstet Gynecol 2002;100:445) or tamoxifen
  • Endocervical sampling devices may inadvertently sample the lower uterine segment or endometrium
Clinical features
Cytology description
  • Exfoliated endometrial cells often present as small cells arranged in balls with scant cytoplasm, dark nuclei and nuclear molding and fragmentation
  • Abraded endometrial cells may present as large and small tissue fragments with glands and stromal cells
  • Resemble histiocytes
  • Easier to identify if in clusters
Cytology images

Contributed by Carmen Luz, M.D.
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Normal endometrial group

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IUD related changes

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Endometrial cells (40x)

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