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Cervix-Cytology

Carcinoma

Glassy cell carcinoma

Reviewer: Marilin Rosa, M.D., University of Florida (see Reviewerspage)
Revised: 9 June 2011, last major update June 2011
Copyright: (c) 2006-2011, PathologyOutlines.com, Inc.

Cytology description
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● Clusters of cells and single cells with distinct cell borders, moderate to abundant finely granulated cytoplasm, large round/oval nuclei with 1 or more prominent nucleoli
● Background of neutrophils, often frequent eosinophils, necrotic debris and proteinaceous material
● High mitotic rate, rare bizarre multinucleated cells, no koilocytes (Acta Cytol 2001;45:407, Acta Cytol 2000;44:551)
● Liquid based cytology: moderately cellular with small clusters of polygonal to elongated tumor cells mixed with amphophilic and granular necrotic debris; tumor cells have discrete cell borders, abundant cyanophilic cytoplasm, round/oval nuclei, thin nuclear membrane, finely dispersed chromatin, prominent nucleoli; may have tumor phagocytosis of neutrophils
● Background of mixed inflammatory cells; no dyskeratosis, cytoplasmic vacuoles or koilocytosis (Acta Cytol 2004;48:99)

Cytology images
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Glassy cell carcinoma

Differential diagnosis
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● Lymphoepithelioma-like carcinoma: Acta Cytol 1999;43:285

End of Cervix-cytology > Carcinoma > Glassy cell carcinoma

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