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Granuloma inguinale

Reviewer: Farnaz Hasteh, M.D., UCSD Medical Center (see Reviewers page)
Revised: 17 November 2010, last major update November 2010
Copyright: (c) 2006-2010, PathologyOutlines.com, Inc.


● Sexually transmitted disease caused by Calymmatobacterium granulomatis, a gram negative organism

Micro description

● Granulomatous inflammation of cervix

Cytology description

● Giant cells in Pap test or a collection of epithelioid histiocytes (granuloma)
● Donovan bodies (intracytoplasmic coccobacilli in macrophages stained by Giemsa or Wright's stain) are seen, may have safety-pin appearance (bipolar densities) in smears taken from scrapings of the edge of lesions, are pleomorphic, up to 2 microns
● Also intact capillaries indicative of ulceration and marked acute inflammatory infiltrate, epithelioid histiocytes (Diagn Cytopathol 1986;2:138)

Cytology images

H&E and Giemsa stain


Intracellular basophilic Donovan bodies

Additional references

Sex Transm Infect 2002;78:452

End of Cervix-cytology > Inflammation/parasites > Granuloma inguinale

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