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Cervix-Cytology

Inflammation/parasites

Granulomas

Reviewer: Farnaz Hasteh, M.D., UCSD Medical Center (see Reviewers page)
Revised: 19 November 2010, last major update November 2010
Copyright: (c) 2006-2010, PathologyOutlines.com, Inc.

Definition
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● Chronic inflammation with epithelioid histiocytes, giant cells and lymphocytes

Terminology
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● Also called granulomatous cervicititis

Epidemiology
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● Uncommon

Etiology
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● Tuberculosis, amebiasis, schistosomiasis, brucellosis, tularemia, sarcoidosis and noninfectious causes like foreign body reaction to sutures (Diagn Cytopathol 1995;13:336)
● Also post-radiation

Case reports
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● Producing psammoma bodies, due to aluminum silicate granuloma (Diagn Cytopathol 1999;21:122)

Micro description
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● Collection of epithelioid histiocytes or granuloma

Cytology description
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● Inflammatory reaction, foreign body giant cells, phagocytosed refractile suture material (in some cases)
● Granuloma rarely seen in Pap test (tuberuclosis)

Cytology images
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Multinucleated histiocytes

   

Epithelioid histiocytes (breast)

Differential diagnosis
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● Fibroblastic proliferation in chronic cervicitis can mimic granuloma (Diagn Cytopathol 2010;38:778)

End of Cervix-cytology > Inflammation/parasites > Granulomas

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