Home   Chapter Home   Jobs   Conferences    Fellowships    Books



Advertisement

Cervix-Cytology

Normal cells / non-neoplastic findings

Hyperkeratosis / keratinization


Reviewer: Marilin Rosa, M.D., University of Florida (see Reviewers page)
Revised: 12 October 2010, last major update August 2010
Copyright: (c) 2006-2010, PathologyOutlines.com, Inc.

Definition
========================================================================

● Patches of anucleated squamous cells with irregular, angulated edges
● In one study, criteria for extensive hyperkeratosis was 5+ low power fields on a conventional smear and 3+ low power fields in liquid based preparation

Clinical
========================================================================

● An abnormal finding; may be associated with malignancy (0-2%) or HPV/dysplasia (17-22%) (Acta Cytol 2003;47:749, Am J Obstet Gynecol 2002;187:997)
● In cases of extensive keratinization, SIL is difficult to grade (Am J Clin Path 2001;115:80)
● Pathology reports of prominent atypical keratosis should state: SIL, grade cannot be determined due to extensive keratosis

Cytology images
========================================================================


   

Various images


Liquid based smear

Differential diagnosis
========================================================================

SIL: irregular chromatin clumping, irregular nuclear membranes, disorganized growth pattern, vno marked hyperkeratosis (Diagn Cytopathol 1997;17:447)

End of Cervix-cytology > Normal cells / non-neoplastic findings > Hyperkeratosis / keratinization


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).