Minimal deviation adenocarcinoma
Reviewer: Nat Pernick, M.D., PathologyOutlines.com, Inc. (see Reviewers page)
Revised: 26 June 2011, last major update June 2011
Copyright: (c) 2006-2011, PathologyOutlines.com, Inc.
● Rare; very well differentiated adenocarcinoma that has malignant behavior
● Also called adenoma malignum
● Combined use of MRI, pap smears and gastric mucin testing may improve preoperative diagnostic accuracy (Int J Gynecol Cancer 2011 Jun 16 [Epub ahead of print])
● Cervical smears often normal
● May have glandular cells ranging from atypical to suspicious for well differentiated adenocarcinoma
● Glandular cells are enlarged and present in honeycombed sheets with abundant cytoplasm, uniform nuclei with fine chromatin and small nucleoli; no pleomorphism, no/rare mitotic figures (Am J Clin Pathol 1996;105:327); may have golden yellow mucin with Pap stain (Diagn Cytopathol 2002;27:80, Cancer 1999;87:245)
End of Cervix-cytology > Carcinoma > Minimal deviation adenocarcinoma
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