Cervix - cytology - Malignant mixed mullerian tumor (MMMT)

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Cervix-cytology

Sarcoma / lymphoma / other

Malignant mixed mullerian tumor (MMMT)

Reviewer: Nat Pernick, M.D., PathologyOutlines.com, Inc. (see Reviewers page)
Revised: 27 June 2011, last major update June 2011
Copyright: (c) 2006-2011, PathologyOutlines.com, Inc.

General
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● Also called carcinosarcoma
● Conventional pap smear is only 60% sensitive for carcinosarcoma (Am J Clin Pathol 2004;122:434)
● Diagnosis is often carcinoma without a mesenchymal component (Diagn Cytopathol 1992;8:33)

Cytology description
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● Findings are often present if advanced stage uterine disease with involvement of lower uterine segment or cervix; usually large numbers of high grade malignant cells with necrosis, occasional mitotic figures, usually no mesenchymal component present (Diagn Cytopathol 2003;28:245, Acta Cytol 2002;46:465)

Cytology images
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Various images

Positive stains
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● Both components: EMA, keratin, vimentin (most)
● Sarcomatous component: muscle specific actin or smooth muscle actin, desmin

End of Cervix-cytology > Sarcoma / lymphoma / other > Malignant mixed mullerian tumor (MMMT)

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