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Cervix-Cytology

Atypia / premalignant / preinvasive lesions

Pagetís disease


Reviewer: Marilin Rosa, M.D., University of Florida (see Reviewers page)
Revised: 8 June 2011, last major update June 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Definition
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● Extramammary Pagetís disease of vulva is rare; ~ 2% of vulvar neoplasms (Diagn Cytopathol 2005;32:353)
● Infrequently involves cervix and vagina and can be detected on pap smears

Case reports
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● 78 year old woman with extensive disease detected by pap smear (Arch Pathol Lab Med 1988;112:941)

Cytology
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● Large cells with high N/C ratio, round nuclei, large nucleoli, clumped chromatin, and occasional large cytoplasmic vacuoles
● Alsp pseudocannibalism, signet ring cells

Cytology images
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Vulvar disease extending into vagina

Positive stains
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● Mucicarmine

Differential Diagnosis
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● Squamous intraepithelial lesion, non-keratinizing squamous cell carcinoma, adenocarcinoma

End of Cervix-cytology > Atypia / premalignant / preinvasive lesions > Pagetís disease


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