Cervix - Cytology
Atypic / premalignant / preinvasive lesions
Paget disease

Topic Completed: 1 June 2011

Revised: 27 December 2018, last major update June 2011

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PubMed search: Paget disease cervix

Marilin Rosa, M.D.
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Cite this page: Rosa M. Paget disease. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixcytologypagets.html. Accessed January 28th, 2020.
Definition / general
  • Extramammary Paget disease of vulva is rare; ~ 2% of vulvar neoplasms (Diagn Cytopathol 2005;32:353)
  • Infrequently involves cervix and vagina and can be detected on pap smears
Case reports
Cytology description
  • Large cells with high N/C ratio, round nuclei, large nucleoli, clumped chromatin and occasional large cytoplasmic vacuoles
  • Alsp pseudocannibalism, signet ring cells
Positive stains
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