Atypia / premalignant / preinvasive lesions
Reviewer: Marilin Rosa, M.D., University of Florida (see Reviewers page)
Revised: 8 June 2011, last major update June 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.
● Extramammary Pagetís disease of vulva is rare; ~ 2% of vulvar neoplasms (Diagn Cytopathol 2005;32:353)
● Infrequently involves cervix and vagina and can be detected on pap smears
● 78 year old woman with extensive disease detected by pap smear (Arch Pathol Lab Med 1988;112:941)
● Large cells with high N/C ratio, round nuclei, large nucleoli, clumped chromatin, and occasional large cytoplasmic vacuoles
● Alsp pseudocannibalism, signet ring cells
Vulvar disease extending into vagina
● Squamous intraepithelial lesion, non-keratinizing squamous cell carcinoma, adenocarcinoma
End of Cervix-cytology > Atypia / premalignant / preinvasive lesions > Pagetís disease
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