Cervix - Cytology
Benign cells / nonneoplastic lesions

Author: Farnaz Hasteh, M.D. (see Authors page)

Revised: 17 May 2017, last major update December 2010

Copyright: (c) 2006-2017, PathologyOutlines.com, Inc.

PubMed search: Parakeratosis cervix

Cite this page: Parakeratosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixcytologyparakeratosis.html. Accessed October 17th, 2018.
Definition / general
  • Defined histologically as abnormal keratinization of the squamous epithelium with persistence of the cell nuclei in the superficial cells
  • Due to SIL or infection
Clinical features
  • Associated with dysplasia more commonly than hyperkeratosis
Cytology description
  • Usually small, round or polygonal squamous cells with dense orangophilic to eosinophilic cytoplasm and pyknotic nuclei
  • Single flat cells, layered strips or "pearls"
  • Can be associated with inflammation (like fungus)
  • May be associated with SIL (Am J Obstet Gynecol 2002;187:997)
  • SIL cases tend to have irregular chromatin clumping, irregular nuclear membranes, disorganized growth pattern, less hyperkeratosis (Diagn Cytopathol 1997;17:447)
Cytology images

Images hosted on other servers:

Parakeratosis - various images

Parakeratosis, suggestive of LSIL

Contributed by Dr. Marilin Rosa, University of Florida (USA)