Cervix - Cytology
Benign cells / nonneoplastic lesions

Topic Completed: 1 December 2010

Revised: 21 December 2018, last major update December 2010

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PubMed search: Parakeratosis cervix

Farnaz Hasteh, M.D.
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Cite this page: Hasteh F. Parakeratosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixcytologyparakeratosis.html. Accessed October 21st, 2019.
Definition / general
  • Defined histologically as abnormal keratinization of the squamous epithelium with persistence of the cell nuclei in the superficial cells
  • Due to SIL or infection
Clinical features
  • Associated with dysplasia more commonly than hyperkeratosis
Cytology description
  • Usually small, round or polygonal squamous cells with dense orangophilic to eosinophilic cytoplasm and pyknotic nuclei
  • Single flat cells, layered strips or "pearls"
  • Can be associated with inflammation (like fungus)
  • May be associated with SIL (Am J Obstet Gynecol 2002;187:997)
  • SIL cases tend to have irregular chromatin clumping, irregular nuclear membranes, disorganized growth pattern, less hyperkeratosis (Diagn Cytopathol 1997;17:447)
Cytology images

Images hosted on other servers:

Parakeratosis - various images

Parakeratosis, suggestive of LSIL

Contributed by Dr. Marilin Rosa, University of Florida (USA)

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